| 第二代抗癌药物卡铂与L-硒代蛋氨酸和L-蛋氨酸的相互作用研究 |
| The Interaction between the Second Generation Anticancer Drug Carboplatin and L-Selenomethionine |
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| 摘要: |
| 关键词: 卡铂 L-硒代蛋氨酸 蛋氨酸 电喷雾质谱(ESMS) 核磁(NMR) |
| 基金项目: |
| Abstract: The reactions of carboplatin ([Pt(NH3)2(CBDCA)], in which CBDCA is cyclobutane-1,1,-dicarboxylate) with L-selenomethionine (L-Se-MetH) and L-methionine (L-MetH) were investigated using electrospray mass spectroscopy (ESMS) and 2D[ 1H-15N] HSQC NMR spectroscopy. The dominant products for both reactions are bis-chelated complexes [Pt(L-Se-Met)2] and [Pt(L-Met)2]. These results are different from those observed for the reactions of cisplatin ([PtCl2(NH3)]) with L-Se-MetH or L-MetH, in which the main products are mono-chelated complexes [PtCl(NH3)(L-Se-Met)] or [PtCl(NH3)(L-Met)]. This work provides insights into the differences between cisplatin and carboplatin in their reactivity and mechanism of reaction. |
| Keywords: carboplatin L-selenomethionine L-methionine ESMS NMR |
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| 摘要点击次数: 1948 |
| 全文下载次数: 1947 |
| 刘琴,林骏,张俊勇,朱龙根,郭子建.第二代抗癌药物卡铂与L-硒代蛋氨酸和L-蛋氨酸的相互作用研究[J].无机化学学报,2002,18(1):37-40. |
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