| 钴(Ⅲ)配合物与DNA作用的研究 |
| Studies of the Interaction of Co(Ⅲ) Complex with DNA |
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| 摘要: 为了考察金属配合物中配体分子平面大小对金属配合物与DNA作用模式的影响,用荧光法和光度法对乙二胺合钴(Ⅲ)([Co(en)3]3+)、联吡啶合钴(Ⅲ)([Co(bpy)3]3+)和邻菲咯啉合钴(Ⅲ)([Co(phen)3]3+)与DNA的作用进行了研究。结果表明[Co(phen)3]3+与DNA作用时除存在静电作用模式外,还存在插入 |
| 关键词: 钴(Ⅲ)配合物 小牛胸腺DNA 插入作用 静电作用 |
| 基金项目: 甘肃省中青年基金资助课题(ZQ95011) |
| Abstract: In order to understand how the size of the ligands' planarties can effect the complexes of binding to DNA, the binding of the complexes [Co(en)3]3+、[Co(bpy)3]3+ and [Co(phen)3]3+ to calf thymus DNA was investigated with spectroscopic and fluorometric methods. The three complexes bind to DNA by electrostatic fashion, for [Co(phen)3]3+ also exists intercalation mode. The intercalate binding affinities was consistent with the ligands's planarities. |
| Keywords: cobalt(Ⅲ) calf thymus DNA intercalative binding electrostatic binding |
| 投稿时间：1999-03-11 修订日期：1999-05-12 |
| 摘要点击次数: 1498 |
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| 宋玉民,康敬万,高锦章,冯亚非.钴(Ⅲ)配合物与DNA作用的研究[J].无机化学学报,2000,16(1):53-57. |
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