| 粉防己碱拮抗α-石英细胞毒性的机理 |
| MECHANISM OF ANTAGONISM OF TETRANDRINE TO CYTOTOXICITY OF α-QUARTZ |
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| 摘要: 借助于单细胞阳离子测定系统研究了α-石英诱发细胞毒性过程中，不同外钙浓度时粉防己碱作用后，细胞存活率与胞浆游离钙浓度的变化关系。研究发现粉防己碱可以通过阻断细胞离子通道，拮抗α-石英的细胞毒性。 |
| 关键词: 粉防己碱 α-石英 细胞毒性 硅肺 钙离子 |
| 基金项目: |
| Abstract: By use of the AR-CM-MIC system, the relationship between cell′s survival rate of alveolar macrophages and the change of plasmic free Ca2+ concentration (［Ca2+］iα-quartz and tetrandrine was investigated under different extracellular Ca2+ concentration. The results showed that tetrandrine could antagonize the cytotoxicity of α-quartz by blocking the calcium channels of alveolar macrophages. |
| Keywords: tetrandrine α-quartz cytotoxicity silicosis calcium ion |
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| 朱卫华,陈瑶,孟翠利,王金晞.粉防己碱拮抗α-石英细胞毒性的机理[J].无机化学学报,1999,15(3):310-314. |
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