| 硒酸酯多糖抗石英细胞毒性的研究 |
| RESEARCH OF ANTAGONISM OF KAPPASELENOCARRAGEENAN TO CYTOTOXITY OF QUARTZ |
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| 摘要: 本文采用家兔肺泡巨噬细胞(AM)体外培养法,以AR-CM阳离子测定系统和荧光试剂Fura-2.研究了石英细胞毒性与肺泡巨噬细胞胞浆游离Ca2+浓度([Ca2+]i)的关系.并以细胞存活率、乳酸脱氢酸(LDH)活性和脂质过氧化物(LPO)表征了由石英引起的AM毒性及硒酸酯多糖对其毒性的拮抗效应,初步讨论了硒酸酯多糖拮抗石英细胞毒性的可能机理. |
| 关键词: 硒酸酯多糖 石英 细胞毒性 胞浆游离Ca2+浓度 |
| 基金项目: 国家自然科学基金 |
| Abstract: In this article, the relation between the eytotoxicity of quartz and the change of cytoplasmic free Ca2+ of alveolar macrophage was studied by means of AR-CM cation measurement system and fluorescence solvent Fura-2. Both the cytotoxicity of quartz and the antagonized effects of Kappa-selenocarrageenan were characterized by the survival percent of cells, the activities of LDH and LPO as well. In addition, the mechanism of Kappa-selenocarragcenan's suppressing cytotoxicity of quartz was also disscussed. |
| Keywords: Kappa-selenocarrageenan quartz cytotoxicity cytoplasmic free Ca2+ |
| 投稿时间：1994-01-25 |
| 摘要点击次数: 1421 |
| 全文下载次数: 1791 |
| 刘永民,王金晞,朱卫华,魏金华,陈荣三.硒酸酯多糖抗石英细胞毒性的研究[J].无机化学学报,1995,11(1):24-28. |
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