| 螯合剂对结合在人血清白蛋白(HSA)上的铜离子活动化能力的研究 |
| STUDIES OF MOBILIZING POWER OF CHELATING AGENTS TOWARD HUMAN SERUM ALBUMIN BOUND COPPER(Ⅱ) |
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| 摘要: 用凝胶色谱法研究了螯合剂使结合在人血清白蛋白上的铜(Ⅱ)活动化的能力,若用在螯合剂存在时和无螯合剂存在时蛋白部分结合金属量之比作为表征活动化能力的参数,有如下顺序:Trien>DTPA>EDTA>EGTA>NTA>IDA除Trien和DTPA外,其他几种螯合剂的活动化能力的对数值与其相应的条件稳定常数的对数值之间有一线性关系.Trien和DTPA的反常被认为与复杂的反应历程有关,这可能涉及三元配合物的形成. |
| 关键词: 人血清白蛋白 金属铜 螯合剂 活动化 |
| 基金项目: 国家自然科学基金资助课题 |
| Abstract: The mobilization of human scrum albumin(HSA)bound Cu(Ⅱ)with chelating agents was studied by means of gel chromatography. The mobilizing power is expressed in terms of the ratio between protein-bound metal in presence and absence of chelators. Thus the sequences of mobilizing power were determined as follows:Trien>DTPA > EDTA >EGTA>NTA>IDAA linear relation between the mobilizing power and conditional stabilities of the chclatcs except Trien-Cu(Ⅱ and DTPA-Cu(Ⅱ)has been observed. It has been suggested that the abnormality of Trien and DTPA was related to the complicated reaction course involving the mechanisms of forming ternary complex. |
| Keywords: human serum albumin copper chelator mobilization |
| 投稿时间：1988-05-30 |
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| 高黎明,李荣昌,王夔.螯合剂对结合在人血清白蛋白(HSA)上的铜离子活动化能力的研究[J].无机化学学报,1991,7(1):12-17. |
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